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dc.contributor.authorErgeneoglu, Pinar
dc.contributor.authorAkin, Sule
dc.contributor.authorBali, Cagla
dc.contributor.authorEker, Hatice Evren
dc.contributor.authorCok, Oya Yalcin
dc.contributor.authorAribogan, Anis
dc.date.accessioned2019-10-06T11:51:22Z
dc.date.available2019-10-06T11:51:22Z
dc.date.issued2015
dc.identifier.issn0034-7094
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0104001415000342?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/11727/4058
dc.description.abstractBackground and objective: Sedation in dialysis dependent end-stage renal disease patients requires caution as a result of performing high doses of sedatives and its complications. Multidrug sedation regimens might be superior and advantage on lesser drug consumption and by the way adverse events which occur easily in end-stage renal disease patients. We evaluated the effects of dexmedetomidine premedication on propofol consumption, sedation levels with Observer's Assessment of Alertness and Sedation scores and the bispectral index and the hemodynamic changes, potential side effects in geriatric patients with end-stage renal disease who underwent hip fracture surgery under spinal anesthesia. Method: In this randomized, controlled, double-blind study 60 elderly patients (age >= 65 years) with end-stage renal disease and hip fracture scheduled for anterograde femoral intramedullary nailing were assigned to groups that received either intravenous saline infusion (Group C) or dexmedetomidine 0.5 mu g/kg/10 min infusion for premedication (Group D). All the patients received propofol infusion after the induction of the spinal anesthesia. Results: Total propofol consumption, propofol dose required for targeted sedation levels according to Observer's Assessment of Alertness and Sedation scores and bispectral index levels, recovery times were significantly lower in Group D (p< 0.001). The time to reach to Observer's Assessment of Alertness and Sedation score 4 and to achieve bispectral index <= 80 was significantly lower in Group C compared with Group D (p< 0.001). Adverse events were similar in both groups. Conclusion: Dexmedetomidine premedication lowers intraoperative propofol consumption to maintain targeted level of sedation. Therefore low dose dexmedetomidine premedication in addition to propofol infusion might be an alternative in geriatric patients with end-stage renal disease for sedation. (c) 2015 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.bjane.2014.11.002en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeriatric patienten_US
dc.subjectEnd stage renal diseaseen_US
dc.subjectDexmedetomidineen_US
dc.subjectPropofolen_US
dc.titleEffect of low dose dexmedetomidine premedication on propofol consumption in geriatric end stage renal disease patientsen_US
dc.typearticleen_US
dc.relation.journalREVISTA BRASILEIRA DE ANESTESIOLOGIAen_US
dc.identifier.volume65en_US
dc.identifier.issue5en_US
dc.identifier.startpage326en_US
dc.identifier.endpage332en_US
dc.identifier.wos000362461200003en_US
dc.identifier.scopus2-s2.0-84941599567en_US
dc.contributor.pubmedID26323728en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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