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dc.contributor.authorOzdogdu, Halkan
dc.contributor.authorBoga, Can
dc.date.accessioned2019-10-03T12:09:27Z
dc.date.available2019-10-03T12:09:27Z
dc.date.issued2015
dc.identifier.issn1300-7777
dc.identifier.urihttp://www.journalagent.com/tjh/pdfs/TJH_32_3_195_205.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4046
dc.description.abstractSickle cell disease-related organ injuries cannot be prevented despite hydroxyurea use, infection prophylaxis, and supportive therapies. As a consequence, disease-related mortality reaches 14% in adolescents and young adults. Hematopoietic stem cell transplantation is a unique curative therapeutic approach for sickle cell disease. Myeloablative allogeneic hematopoietic stem cell transplantation is curative for children with sickle cell disease. Current data indicate that long-term disease-free survival is about 90% and overall survival about 95% after transplantation. However, it is toxic in adults due to organ injuries. In addition, this curative treatment approach has several limitations, such as difficulties to find donors, transplant-related mortality, graft loss, graft-versus-host disease (GVHD), and infertility. Engraftment effectivity and toxicity for transplantations performed with nonmyeloablative reduced-intensity regimens in adults are being investigated in phase 1/2 trials at many centers. Preliminary data indicate that GVHD could be prevented with transplantations performed using reduced-intensity regimens. It is necessary to develop novel regimens to prevent graft loss and reduce the risk of GVHD.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4274/tjh.2014.0311en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSickle cell diseaseen_US
dc.subjectHematopoietic stem cell transplantationen_US
dc.subjectGraft-versus-host diseaseen_US
dc.subjectGraft rejectionen_US
dc.subjectConditioningen_US
dc.titleHematopoietic Stem Cell Transplantation in Adult Sickle Cell Disease: Problems and Solutionsen_US
dc.typereviewen_US
dc.relation.journalTURKISH JOURNAL OF HEMATOLOGYen_US
dc.identifier.volume32en_US
dc.identifier.issue3en_US
dc.identifier.startpage195en_US
dc.identifier.endpage205en_US
dc.identifier.wos000363092000001


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