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dc.contributor.authorBal, Z.
dc.contributor.authorDemirci, B.G.
dc.contributor.authorKarakose, S.
dc.contributor.authorTutal, E.
dc.contributor.authorUyar, M.E.
dc.contributor.authorAcar, N.O.
dc.contributor.authorSezer, S.
dc.date.accessioned2019-06-30T19:19:30Z
dc.date.available2019-06-30T19:19:30Z
dc.date.issued2018
dc.identifier.issn23566140
dc.identifier.urihttps://www.hindawi.com/journals/tswj/2018/8065691/
dc.identifier.urihttp://hdl.handle.net/11727/3756
dc.description.abstractPurpose. We aimed to investigate the factors influencing hemoglobin variability with inflammatory and nutritional parameters and its associations with all-cause mortality among hemodialysis patients. Methods. One hundred and sixty-nine patients during the entire 12 months were enrolled into the study. Fasting plasma glucose, creatinine, calcium, phosphorus, alkaline phosphatase, parathyroid hormone (PTH), C-reactive protein (CRP), serum iron, serum iron-binding capacity, and transferrin saturation were analyzed. We defined six groups: low, target range, high, low-Amplitude fluctuation with low hemoglobin levels, low-Amplitude fluctuation with high hemoglobin levels, and high-Amplitude fluctuation. Body mass index (BMI), malnutrition-inflammation score (MIS), and Charlson Comorbidity Index were evaluated. Results. Hemoglobin variability was significantly correlated with age, platelet count, and number of hospitalization instances and inversely correlated with erythropoietin dose per body surface area. The coefficient of variation of hemoglobin showed a correlation with MIS and ferritin. The absolute level of hemoglobin showed a negative correlation between PTH, CRP, MIS, number of hospitalization instances and a positive correlation with albumin and BMI. High, low, and target-range groups showed survival advantage compared to the other three groups. In regression analysis, age, CRP levels, MIS, and BMI were the predictors of mortality. Conclusion. Inflammation and duration of anemia were the major predictors of hemoglobin variability. High-Amplitude fluctuation predicts high mortality; on the contrary low-Amplitude fluctuations is related to better survival. MIS was independently associated with mortality. This trial is registered with NCT03454906. © 2018 Zeynep Bal et al.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1155/2018/8065691en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalkaline phosphataseen_US
dc.subjectantianemic agenten_US
dc.subjectC reactive proteinen_US
dc.subjectcalciumen_US
dc.subjectcreatinineen_US
dc.subjectglucoseen_US
dc.subjecthemoglobinen_US
dc.subjectironen_US
dc.subjectparathyroid hormoneen_US
dc.subjectphosphorusen_US
dc.subjecttransferrinen_US
dc.subjecthemoglobinen_US
dc.titleFactors influencing hemoglobin variability and its association with mortality in hemodialysis patientsen_US
dc.typearticleen_US
dc.relation.journalScientific World Journalen_US
dc.identifier.volume2018en_US
dc.identifier.scopus2018-34


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