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dc.contributor.authorYücel, Ayşegül
dc.contributor.authorKöseoğlu, Hamide
dc.contributor.authorYücel, Ahmet Eftal
dc.contributor.authorÖzdemir, Nurhan
dc.contributor.authorHaberal, Mehmet
dc.date.accessioned2015-03-02T13:12:18Z
dc.date.available2015-03-02T13:12:18Z
dc.date.issued2001
dc.identifier.urihttp://uvt.ulakbim.gov.tr/uvt/index.php?cwid=9&vtadi=TPRJ%2CTTAR%2CTTIP&ano=14386_81d1dc34d5437b514b4e14ce33805daa
dc.identifier.urihttp://hdl.handle.net/11727/2041
dc.description.abstractHepatitis C virüs (HCV) positivity and inflammatory cytokines such as interleukin(IL)-} beta, tumor necrosis factor-alpha and IL-6 secreted by activated macrophages are known to be important morbidity factors in chronic hemodialysis (HD) patients. in this preliminary stııdy, we aimed to compare serum IL-1 beta levels of 20 HCV-RNA-positive and 23 HCV-RNA-negative chronic HD patients. Methods: HCV-RNA-positivity and serum IL-1 beta levels were studied using nested reverse transcriptase-polymerase chain reaction and ELISA methods, respectively. Results: We could detect no statistically signifıcant difference between serum IL-1 beta levels in HCV-RNA-positive and HCV-RNA-negative groups (p>0.05). Conclusion: To our knowledge, this is the fırst study to examine the relationship between serum IL-1 beta level and HCV infection in HD patients. We had expected the level of IL-1 beta to be higher in HCV-RNA-positive group, and believe that the blood-dialyzer interaction strongly activated mononuclear cells, thus generating elevated levels of IL-1 beta in both groups. This could explain why HCV infection apparently did not affect serum IL-1 beta levels.en_US
dc.language.isoturen_US
dc.publisherGazi Medical Journal ,12 ,4 ,155-158en_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytokinesen_US
dc.subjectEnzyme-Linked Immunosorbent Assayen_US
dc.subjectHemodialysisen_US
dc.subjectHepacivirusen_US
dc.subjectHepatitis C Antibodiesen_US
dc.subjectInterleukin-1en_US
dc.subjectTumor Necrosis Factoren_US
dc.titleEffects of HCV-RNA positivity on serum IL-1 beta levels in chronic hemodialysis patientsen_US
dc.typearticleen_US
dc.identifier.volume12
dc.identifier.startpage155
dc.identifier.endpage158


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