Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
http://hdl.handle.net/11727/4806
2024-03-28T20:23:32ZCould Plasma Asymmetric Dimethylarginine Level Be A Novel Predictor Beyond The Classic Predictors of Stent Restenosis?
http://hdl.handle.net/11727/11186
Could Plasma Asymmetric Dimethylarginine Level Be A Novel Predictor Beyond The Classic Predictors of Stent Restenosis?
Bal, Ugur Abbas; Yildirir, Aylin; Aydinalp, Alp; Kaynar, Gamze; Kanyilmaz, Suleyman; Murat, Koza; Muderrisoglu, Ibrahim Haldun
Objective: The aim of this study was to investigate the factors associated with coronary stent restenosis and if there is an association between plasma asymmetric dimethylarginine (ADMA) levels and stent restenosis.
Methods: Ninety-one patients, who had a history of coronary bare metal stent implantation due to any cause in the last one year period, were admitted to this observational cross-sectional study. Coronary angiography was performed to all patients and quantitative angiography was used to determine the presence of stent restenosis. Laboratory parameters and angiographic features that contribute to stent restenosis were evaluated. Plasma ADMA levels were measured by using high performance liquid chromatography. Logistic regression analysis was used to determine the independent factors of stent restenosis.
Results: Angiographic restenosis was found in 35 patients (38.5%). Stent diameter (p=0.038) and left ventricular ejection fraction (p=0.023) were lower and stent implantation history due to acute coronary syndrome (p=0.029), plasma ADMA level (5.0 +/- 1.8x10(-4) mmol/L vs. 3.9 +/- 1.0x10(-4) mmol/L, p=0.001), C-reactive protein concentration (p=0.016), white blood cell count (p=0.044) and stent length (p=0.005) were higher in patients with restenosis. Plasma ADMA level (beta=0.536; OR: 1.710; CI: 1.022-2.861; p=0.041), C-reactive protein concentration (beta=0.062; OR: 1.064; CI: 1.003-1.129; p=0.041), stent diameter (beta=-3.047; OR: 0.048; CI: 0.007-0.313; p=0.002) and length (beta=0.165; OR: 1.179; CI: 1.036-1.343; p=0.013) were found to be the independent predictors of stent restenosis in logistic regression analysis.
Conclusion: We conclude that plasma ADMA levels may be used as a novel marker for stent restenosis beyond the classic stent restenosis markers.
2014-01-01T00:00:00ZEvaluation of Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography in Patients with Severe Obstructive Sleep Apnea Syndrome: A Comparative Study
http://hdl.handle.net/11727/11056
Evaluation of Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography in Patients with Severe Obstructive Sleep Apnea Syndrome: A Comparative Study
Karalezli, Aylin; Eroglu, Fatma Corak; Kivanc, Tulay; Dogan, Rasina
AIM: To assess choroidal thickness in patients with severe obstructive sleep apnea syndrome (OSAS) and compare them with healthy controls, using spectral domain optical coherence tomography (OCT).
METHODS: In this observational, cross-sectional study, choroidal thicknesses of 23 newly severe OSAS patients and 23 body mass index- age- and sex-matched healthy subjects were measured using a high -speed, high resolution frequency domain-OCT device (lambda=840 nm, 26 000 A -scans/s, 5 pm axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day (9:00 a.m.), in order to minimize the effects of diurnal variation.
RESULTS: There was a statistically significant difference in median choroidal thickness between the OSAS patients (201 pm; range 145 -237 pm) and the controls (324 pm; range 296 -383 mu m; P <0.001). There were significant differences at all measurement points (P <0.001 for all). The apnea -hypopnea index (AHI) values were more than 30 in all OSAS patients and the mean AHI was 48.57 +/- 6.54. The interexaminer intraclass correlation coefficient (ICC) for the mean choroidal thickness was 0.938 (95%CI, 0.908-0.985) and ICC was greater than 0.90 for all measurement points.
CONCLUSION: The decreased choroidal thickness of patients with severe OSAS might be related to the the autonomic disregulation associated with this disease. Further studies are needed to evaluate the etiopathologic relationship between choroidal thickness and OSAS.
2014-01-01T00:00:00ZCoexistence of Familial Mediterranean Fever and Hyperimmunoglobulinemia D Syndrome in a Child
http://hdl.handle.net/11727/10884
Coexistence of Familial Mediterranean Fever and Hyperimmunoglobulinemia D Syndrome in a Child
Yilmaz, Resul; Sezer, Taner; Esmeray, Haluk
Hereditary periodic fever syndromes are Mendelian inherited single gene diseases which are also known as hereditary autoinflammatory syndromes, are characterized by recurrent attacks of fever and inflammation. Familial Mediterranean Fever and Hyperimmunoglobulinemia D syndrome are prototypes and are inherited autosomal recessively. The diagnosis is based on clinical course, family history and is confirmed with genetic mutation analysis. We describe a 5-year-old boy who had recurrent attacks of fever, skin rash, and cervical lymphadenopathy since he was 2 years old. His genetic analysis revealed homozygous M694V and V377I for MEFV and MVK gene respectively. Due to our knowledge, this is the first report of a patient who has both HIDS and FMF clinical and genetic features.
2015-01-01T00:00:00ZCorrelations Between Problem Domain and Solution Domain Size Measures for Open Source Software
http://hdl.handle.net/11727/10863
Correlations Between Problem Domain and Solution Domain Size Measures for Open Source Software
Ayyildiz, Tulin Ercelebi; Kocyigit, Altan
Predicting how much effort will be required to complete a software project as early as possible is a very important factor in the success of software development projects. Including function points and its variants, there are several size measures and corresponding measurement methods that can be used for effort estimation. However, in most of the projects, there is limited amount of information available in the early stages and significant effort is spent for size measurement and effort estimation with such methods. This paper analyzes the correlation between the size metrics of conceptual model of the problem domain and the resulting software. For this purpose, we consider open source project management and game software. We apply linear regression and cross validation techniques to investigate the relation between the sizes of problem domain (i.e., conceptual) and solution domain (i.e., design) models. The results reveal a high correlation between the number of conceptual classes in the problem domain model and the number of software classes constituting the corresponding software. The results suggest that it is possible to use problem domain descriptions in the early stages of software development projects to make plausible predictions for the size of the software.
2014-01-01T00:00:00Z