The Significance of Mean Platelet Volume in Acute Pancreatitis

Abstract

Aim: Acute pancreatitis is a high-mortality disease carrying significant risk of complications and characterized by intra-acinar cell activation of digestive enzymes, followed by a subsequent response via the release of proin-flammatory cytokines. Here, we aimed to investigate the development of mean platelet volume in patients diagnosed with acute pancreatitis. Material and Method: The study was performed in patients admitted to the emergency room with the complaint of abdominal pain and diagnosed with acute pancreatitis. A total of 116 patients were included in the study. Mean platelet volume, leucocytes or white blood cells and lipase values were investigated and compared after all patients had been diagnosed with acute pancreatitis and regained good health. Also, the values of mean platelet volume, white blood cells and lipase were recorded twice for these patients. Results: After diagnosis and complete treatment, the mean platelet volume, white blood cells and the lipase values of 116 acute pancreatitis patients were statistically compared it was found that the values on admission were higher than after the treatment. Discussion: Mean platelet volume is an indicator that increases in acute pancreatitis so, we consider that mean platelet volume may be beneficial in the diagnosis and in monitoring the course of acute pancreatitis.