Dermatoscopy Of Nodular/Plaque-Type Primary Cutaneous T- And B-Cell Lymphomas: A Retrospective Comparative Study With Pseudolymphomas And Tumoral/Inflammatory Mimickers By The International Dermoscopy Society
Tarih
2022Yazar
Errichetti, Enzo
Geller, Shamir
Zalaudek, Iris
Longo, Caterina
Kyrgidis, Athanassios
Akay, Bengu Nisa
Piccolo, Vincenzo
Myskowski, Patricia
Vitiello, Paola
Russo, Teresa
Argenziano, Giuseppe
Slawinska, Martyna
Sokolowska-Wojdylo, Malgorzata
Sobjanek, Michal
Toncic, Ruzica Jurakic
Rados, Jaka
Drvar, Daniela Ledic
Ceovic, Romana
Kaminska-Winciorek, Grazyna
Lanssens, Sven
Gulec, Ayse Tulin
Lobato-Berezo, Alejandro
Damiani, Giovanni
Maione, Vincenzo
Calzavara-Pinton, Piergiacomo
Sotiriou, Elena
Stinco, Giuseppe
Apalla, Zoe
Lallas, Aimilios
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Background: Limited data on dermatoscopy of nodular/plaque-type T-/B-cell primary cutaneous lymphomas (PCLs) is available. Objective: To describe dermatoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histologic subtypes. Methods: Participants were invited to join this retrospective, multicenter case-control study by submitting histologically/immunohistochemically confirmed instances of nodular/plaque-type PCLs and controls. Standardized assessments of the dermatoscopic images and comparative analyses were performed. Results: A total of 261 lesions were included (121 PCLs and 140 controls). Orange structureless areas were the strongest PCL dermatoscopic predictor on multivariate analysis compared with tumors and non infiltrative inflammatory dermatoses. On the other hand, a positive association was found between PCLs and either unfocused linear vessels with branches or focal white structureless areas compared with infiltrative inflammatory dermatoses, whereas white lines were predictive of PCLs over pseudolymphomas. Differences in the vascular pattern were also seen between B-and T-cell PCLs and among B-cell PCL subtypes. Limitations: Retrospective design and the lack of a dermatoscopic-pathologic correlation analysis. Conclusion: Nodular/plaque-type PCLs display dermatoscopic clues, which may partially vary according to histologic subtype and whose diagnostic relevance depends on the considered clinical differential diagnoses. ( J Am Acad Dermatol 2022;86:774-81.)