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dc.contributor.authorKocabas, Umut
dc.contributor.authorKivrak, Tarik
dc.contributor.authorYilmaz Oztekin, Gulsum Meral
dc.contributor.authorTanik, Veysel O.
dc.contributor.authorOzdemir, Ibrahim
dc.contributor.authorKaya, Ersin
dc.contributor.authorYuce, Elif Ilkay
dc.contributor.authorAvci Demir, Fulya
dc.contributor.authorDogdus, Mustafa
dc.contributor.authorAltinsoy, Meltem
dc.contributor.authorUstundag, Songul
dc.contributor.authorOzyurtlu, Ferhat
dc.contributor.authorKaragoz, Ugur
dc.contributor.authorKarakus, Alper
dc.contributor.authorUrgun, Orsan Deniz
dc.contributor.authorSinan, Umit Yasar
dc.contributor.authorMutlu, Inan
dc.contributor.authorSen, Taner
dc.contributor.authorAstarcioglu, Mehmet Ali
dc.contributor.authorKinik, Mustafa
dc.contributor.authorOzden Tok, Ozge
dc.contributor.authorUygur, Begum
dc.contributor.authorYeni, Mehtap
dc.contributor.authorAlan, Bahadir
dc.contributor.authorDalgic, Onur
dc.contributor.authorAltay, Hakan
dc.contributor.authorPehlivanoglu, Seckin
dc.date.accessioned2020-12-31T12:22:09Z
dc.date.available2020-12-31T12:22:09Z
dc.date.issued2020
dc.identifier.issn1368-5031en_US
dc.identifier.urihttp://hdl.handle.net/11727/5366
dc.description.abstractAim Gender-related differences have been described in the clinical characteristics and management of patients with chronic heart failure with reduced ejection fraction (HFrEF). However, published data are conflictive in this regard. Methods We investigated differences in clinical and management variables between male and female patients from the ATA study, a prospective, multicentre, observational study that included 1462 outpatients with chronic HFrEF between January and June 2019. Results Study population was predominantly male (70.1%). In comparison to men, women with chronic HFrEF were older (66 +/- 11 years vs 69 +/- 12 years, P < .001), suffered more hospitalisations and presented more frequently with NYHA class III or IV symptoms. Ischaemic heart disease was more frequent in men, whereas anaemia, thyroid disease and depression were more frequent in women. No difference was seen between genders in the use rate of renin-angiotensin system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, or ivabradine, or in the proportion of patients achieving target doses of these drugs. Regarding device therapies, men were more often treated with an implantable cardioverter-defibrillator (ICD) and women received more cardiac resynchronisation therapy. Conclusion In summary, although management seemed to be equivalent between genders, women tended to present with more symptoms, require hospitalisation more frequently and have different comorbidities than men. These results highlight the importance of gender-related differences in HFrEF and call for further research to clarify the causes of these disparities. Gender-specific recommendations should be included in future guidelines in HFrEF.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1111/ijcp.13765en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSEX-DIFFERENCESen_US
dc.subjectMORTALITYen_US
dc.subjectGUIDELINEen_US
dc.subjectANEMIAen_US
dc.subjectAGEen_US
dc.subjectPREVALENCEen_US
dc.subjectPHYSICIANSen_US
dc.subjectPROGNOSISen_US
dc.subjectSURVIVALen_US
dc.subjectOUTCOMESen_US
dc.titleGender-related clinical and management differences in patients with chronic heart failure with reduced ejection fractionen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL JOURNAL OF CLINICAL PRACTICEen_US
dc.identifier.volume75en_US
dc.identifier.issue3en_US
dc.identifier.wos000588830800001en_US
dc.identifier.scopus2-s2.0-85096705585en_US
dc.contributor.pubmedID33063424en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAE-1392-2021en_US


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