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dc.contributor.authorIlhan, Elif
dc.contributor.authorKarahaliloglu, Zeynep
dc.contributor.authorKilicay, Ebru
dc.contributor.authorHazer, Baki
dc.contributor.authorDenkbas, Emir Baki
dc.date.accessioned2020-11-09T06:53:44Z
dc.date.available2020-11-09T06:53:44Z
dc.date.issued2019
dc.identifier.issn1066-7857en_US
dc.identifier.urihttp://hdl.handle.net/11727/5009
dc.description.abstractPostoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (beta-TCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity of the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 beta-TCP) w/w in beta-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1080/10667857.2019.1661157en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone cementen_US
dc.subjectpolystyreneen_US
dc.subjectsilver nanoparticleen_US
dc.subjectsoybean oilen_US
dc.titlePotent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applicationsen_US
dc.typearticleen_US
dc.relation.journalMATERIALS TECHNOLOGYen_US
dc.identifier.volume35en_US
dc.identifier.issue3en_US
dc.identifier.startpage179en_US
dc.identifier.endpage194en_US
dc.identifier.wos000487927500001en_US
dc.identifier.scopus2-s2.0-85073958686en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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