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dc.contributor.authorKaracaglar, Emir
dc.contributor.authorBal, Ugur
dc.contributor.authorEroglu, Serpil
dc.contributor.authorColak, Ayse
dc.contributor.authorBozbas, Serife
dc.contributor.authorMuderrisoglu, Hadun
dc.date.accessioned2020-11-08T13:21:51Z
dc.date.available2020-11-08T13:21:51Z
dc.date.issued2019
dc.identifier.issn1011-6842en_US
dc.identifier.urihttp://hdl.handle.net/11727/5005
dc.description.abstractBackground: Obstructive sleep apnea syndrome (OSAS) leads to right ventricular (RV) dysfunction and pulmonary hypertension (PH) in the later stages. Early determination of these conditions is very important. Objectives: We aimed to evaluate the correlations of pulmonary artery distensibility, right pulmonary artery fractional shortening (RPA-FS), and pulmonary artery stiffness (PAS) with PH among newly diagnosed OSAS patients. Methods: We prospectively evaluated 34 newly diagnosed OSAS patients and 28 controls. The study subgroups were determined according to the apnea-hypopnea index (AHI). All patients underwent a transthoracic echocardiographic examination. Conventional RV parameters, PAS, and RPA-FS parameters were measured. Results: RPA-FS was significantly lower in the OSAS group (p < 0.001) and positively correlated with tricuspid annular systolic excursion (TAPSE) (p = 0.047) and pulmonary acceleration time (PAT) (p = 0.006), and inversely correlated with systolic pulmonary artery pressure (sPAP) (p = 0.013), and PAS (p < 0.001). Consistent with this result, PAS was significantly worse in the patients with OSAS compared to the controls (27.1 +/- 3.5 to 15.8 +/- 2.7, p < 0.001), and inversely correlated with RPA-FS (p < 0.001), PAT (p = 0.001), and TAPSE (p = 0.035). PAS was positively correlated with sPAP (p = 0.001). There were statistically significant differences for both PAS and RPA-FS among the OSAS subgroups with regards to the severity of disease (p < 0.001). The correlation analyses showed a significantly positive correlation between RPA-FS and mean O2 saturation. RPA-FS was also inversely correlated with AHI. Similarly, PAS was positively correlated with AHI and arousal index. Conclusions: PAS and RPA-FS are worsened in patients with OSAS, and are correlated with PH and severity of OSAS.en_US
dc.language.isoengen_US
dc.relation.isversionof10.6515/AC5.201909_35(5).20190424Aen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEchocardiographyen_US
dc.subjectPulmonary artery hypertensionen_US
dc.subjectRight ventricular functionen_US
dc.titlePulmonary Artery Distensibility is Worsened in Obstructive Sleep Apnea Syndromeen_US
dc.typearticleen_US
dc.relation.journalACTA CARDIOLOGICA SINICAen_US
dc.identifier.volume35en_US
dc.identifier.issue5en_US
dc.identifier.startpage501en_US
dc.identifier.endpage507en_US
dc.identifier.wos000487859100007en_US
dc.identifier.scopus2-s2.0-85073452826en_US
dc.contributor.pubmedID31571799en_US
dc.contributor.orcID0000-0003-3055-7953en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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