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dc.contributor.authorCicek, Davran
dc.contributor.authorBalcioglu, Akif Serhat
dc.contributor.authorLakadamyali, Huseyin
dc.contributor.authorMuderrisoglu, Haldun
dc.date.accessioned2019-12-06T08:46:33Z
dc.date.available2019-12-06T08:46:33Z
dc.date.issued2015
dc.identifier.issn1349-2365
dc.identifier.urihttps://www.jstage.jst.go.jp/article/ihj/56/1/56_14-085/_pdf
dc.identifier.urihttp://hdl.handle.net/11727/4334
dc.description.abstractThe objective of the study was to determine the effects of nasal continuous positive airway pressure (nCPAP) therapy on left ventricular (LV) function and electrocardiographic parameters in newly diagnosed moderate/severe obstructive sleep apnea (USA) patients without cardiovascular comorbidities and medical treatments. We examined 44 patients who underwent overnight polysomnography together with 24-hour Ho lter electrocardiography, cardiopulmonary exercise testing including heart rate recovery at 1 minute (HRR-1), echocardiography, surface electrocardiography, and those who were diagnosed with moderate/severe USA apnea-hypopnea index >= 15. After 3 months of nCPAP treatment, the above-mentioned examinations were repeated. Forty-four patients completed the treatment period. Twelve weeks on effective nCPAP induced a significant increase in the mitral E/A ratio (P = 0.001), as well as reductions in isovolumic relaxation time (P = 0.001) and mitral deceleration time (DT) (P = 0.002). There were no significant differences in LV ejection fraction, LV mass index, and pulsed wave Doppler parameters. Mean heart rate was 79.2 +/- 12.5 pulses/minute, maximum P-wave duration 117.5 +/- 8.6 msec, P-wave dispersion (PWd) 54.6 +/- 10.2 msec, corrected QT interval (QTc) 436.5 +/- 40.5 msec, and QT dispersion (QTd) 46.3 +/- 7.1 msec, which significantly decreased to 70.4 +/- 9.6 pulses/minute (P <0.001), 111.5 +/- 8.7 msec (P <0.001), 51.6 +/- 8.9 msec (P <0.001), 418.4 +/- 31.2 msec (P <0.001), and 33.8 +/- 3.4 msec (P < 0.001), respectively. Exercise capacity at baseline determined as 10.5 +/- 2.2 metabolic equivalents (METS) and HRR-1 (20.6 +/- 11.7 bpm) significantly increased (12.1 +/- 1.5 METS and 27.4 +/- 8.6 bpm). There was no significant difference in aortic root parameters. Three-month nCPAP therapy significantly increased LV shortening fraction, with no effect on systolic function or aortic root diameters and a positive effect on heart rate, PWd, HRR-1, QTc and QTd time following nCPAP therapy.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1536/ihj.14-085en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApnea-hypopnea indexen_US
dc.subjectHeart rate recovery timeen_US
dc.subjectLeft ventricular functionen_US
dc.subjectP-wave dispersionen_US
dc.subjectQT corrected intervalen_US
dc.titleEffects of Three Month Nasal Continuous Positive Airway Pressure Treatment on Electrocardiographic, Echocardiographic and Overnight Polysomnographic Parameters in Newly Diagnosed Moderate/Severe Obstructive Sleep Apnea Patientsen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL HEART JOURNALen_US
dc.identifier.volume56en_US
dc.identifier.issue1en_US
dc.identifier.startpage94en_US
dc.identifier.endpage99en_US
dc.identifier.wos000351027800016en_US
dc.identifier.scopus2-s2.0-84921865822en_US
dc.contributor.pubmedID25503651en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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