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dc.contributor.authorIsin, Mustafa
dc.contributor.authorUysaler, Ege
dc.contributor.authorOzgur, Emre
dc.contributor.authorKoseoglu, Hikmet
dc.contributor.authorSanli, Oner
dc.contributor.authorYucel, Omer B.
dc.contributor.authorGezer, Ugur
dc.contributor.authorDalay, Nejat
dc.date.accessioned2019-11-29T16:52:07Z
dc.date.available2019-11-29T16:52:07Z
dc.date.issued2015
dc.identifier.issn1664-8021
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422020/pdf/fgene-06-00168.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4308
dc.description.abstractExosomes are membranous vesicles containing various biomolecules including IncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 IncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of IncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3389/fgene.2015.00168en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectANTIGEN 3en_US
dc.subjectACTIVE SURVEILLANCEen_US
dc.subjectGENE-EXPRESSIONen_US
dc.subjectNONCODING RNASen_US
dc.subjectTUMOR VOLUMEen_US
dc.subjectCELLSen_US
dc.subjectMENen_US
dc.subjectMANAGEMENTen_US
dc.subjectBIOPSYen_US
dc.subjectURINEen_US
dc.titleExosomal IncRNA-p21 levels may help to distinguish prostate cancer from benign diseaseen_US
dc.typearticleen_US
dc.relation.journalFRONTIERS IN GENETICSen_US
dc.identifier.volume6en_US
dc.identifier.wos000359631300001en_US
dc.contributor.pubmedID25999983en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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