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dc.contributor.authorSimsek, Erhan
dc.contributor.authorKilicdag, Esra Bulgan
dc.contributor.authorAytac, Pinar Caglar
dc.contributor.authorCoban, Gonca
dc.contributor.authorSimsek, Seda Yüksel
dc.contributor.authorCok, Tayfun
dc.contributor.authorHaydardedeoglu, Bulent
dc.date.accessioned2019-11-27T08:21:57Z
dc.date.available2019-11-27T08:21:57Z
dc.date.issued2015
dc.identifier.issn1309-0399
dc.identifier.urihttp://cms.galenos.com.tr/Uploads/Article_13430/96-101.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4248
dc.description.abstractObjective: Luteal phase is defective in in vitro fertilization (IVF) cycles, and many regimens were tried for the very best luteal phase support (LPS). Gonadotropin releasing hormone (GnRH) agonist use, which was administered as an adjunct to the luteal phase support in IVF cycles, was suggested to improve pregnancy outcome measures in certain randomized studies. We analyzed the effects of addition of GnRH agonist to standard progesterone luteal support on pregnancy outcome measures, particularly the live birth rates. Material and Methods: This is a retrospective cohort study, including 2739 IVF cycles. Long GnRH agonist and antagonist stimulation IVF cycles with cleavage-stage embryo transfer were included. Cycles were divided into two groups: Group A included cycles with single-dose GnRH agonist plus progesterone LPS and Group B included progesterone only LPS. Live birth rates were the primary outcome measures of the analysis. Miscarriage rates and multiple pregnancy rates were the secondary outcome measures. Results: Live birth rates were not statistically different in GnRH agonist plus progesterone (Group A) and progesterone only (Group B) groups in both the long agonist and antagonist stimulation arms (40.8%/41.2% and 32.8%/34.4%, p<0.05 respectively). Moreover, pregnancy rates, implantation rates, and miscarriage rates were found to be similar between groups. Multiple pregnancy rates in antagonist cycles were significantly higher in Group A than those in Group B (12.0% and 6.9%, respectively). Conclusion: A beneficial effect of a single dose of GnRH agonist administration as a luteal phase supporting agent is yet to be determined because of the wide heterogeneity of data present in literature. Well-designed randomized clinical studies are required to clarify any effect of luteal GnRH agonist addition on pregnancy outcome measures with different doses, timing, and administration routes of GnRH agonists.en_US
dc.language.isoengen_US
dc.relation.isversionof10.5152/jtgga.2015.15007en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGnRH agonisten_US
dc.subjectluteal phase supporten_US
dc.subjectin vitro fertilization (IVF)en_US
dc.subjectprogesteroneen_US
dc.titleAddition of gonadotropin releasing hormone agonist for luteal phase support in in-vitro fertilization: an analysis of 2739 cyclesen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATIONen_US
dc.identifier.volume16en_US
dc.identifier.issue2en_US
dc.identifier.startpage96en_US
dc.identifier.endpage101en_US
dc.identifier.wos000359204800009en_US
dc.identifier.scopus2-s2.0-84930586740en_US
dc.contributor.pubmedID26097392en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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