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dc.contributor.authorOrhan, Betul
dc.contributor.authorMalbora, Baris
dc.contributor.authorBayar, Sezin Akca
dc.contributor.authorAvci, Zekai
dc.contributor.authorAlioglu, Bulent
dc.contributor.authorOzbek, Namik
dc.date.accessioned2019-08-07T12:21:43Z
dc.date.available2019-08-07T12:21:43Z
dc.date.issued2016
dc.identifier.issn1300-0659
dc.identifier.urihttp://cms.galenos.com.tr/Uploads/Article_11763/62-67-ing.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3829
dc.description.abstractObjectives: Ophthalmologic disease in patients with acute leukemia occurs due to primary leukemic infiltration (involvement), or secondary to the disease and its treatment. In recent years the life expectancy of acute leukemia patients has increased with the advent of modern therapies. The present study aimed to determine the incidence of ocular manifestations in children with acute leukemia. Materials and Methods: The study included 120 patients diagnosed with acute leukemia at Baskent University Hospital, Pediatric Hematology Department between 1995 and 2010. All the patients were examined by an ophthalmologist via direct and indirect ophthalmoscopy. Results: Among the patients, 83 (69.2%) were diagnosed with acute lymphoblastic leukemia, 35 (29.1%) with acute myeloblastic leukemia, and 2 (1.7%) with mixed-lineage leukemia. In all, 58 ophthalmic manifestations were noted in 41 patients (34.2%). In our patients, 12 ophthalmologic involvements were present at admission and 46 ocular findings occurred during follow-up. The incidence of these manifestations increased with age. Conclusion: Ophthalmologic manifestations were not correlated with gender, hematological parameters at disease onset, type of leukemia, or the frequency of relapse and survival. To more clearly determine the effect of ophthalmologic manifestations on the prognosis of leukemia, larger scale and multi-center studies are needed.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4274/tjo.03880en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectleukemiaen_US
dc.subjectophthalmologic findingsen_US
dc.titleOphthalmologic Findings in Children with Leukemia: A Single-Center Studyen_US
dc.typearticleen_US
dc.relation.journalTURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGYen_US
dc.identifier.volume46en_US
dc.identifier.issue2en_US
dc.identifier.startpage62en_US
dc.identifier.endpage67en_US
dc.identifier.wos000377797800005


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