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dc.contributor.authorCaldir, Mehmet Vedat
dc.contributor.authorCelik, Guner Koyuncu
dc.contributor.authorCiftci, Ozgur
dc.contributor.authorMuderrisoglu, Ibrahim Haldun
dc.date.accessioned2019-06-13T13:42:39Z
dc.date.available2019-06-13T13:42:39Z
dc.date.issued2017
dc.identifier.issn2149-2263
dc.identifier.urihttps://www.journalagent.com/anatoljcardiol/pdfs/AJC_17_5_392_397.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3515
dc.description.abstractObjective: The cardiovascular effects of short-term high-dose steroid treatment (pulse steroid treatment) have not yet been clarified. We examined the short-and long-term effects of pulse steroid treatment in demyelinating diseases on endothelial and cardiac functions. Methods: In this prospective study, we included 35 patients (20 females and 15 males; mean age, 32.8 +/- 9.3 years) who were not treated with steroids and who were previously diagnosed with multiple sclerosis or neuromyelitis optica. Patients were evaluated before, 1 week after, and 3 months after the steroid treatment. Brachial artery flow-mediated relaxation and cardiac systolic/diastolic function were evaluated using echocardiography to assess physical examination results, carotid intima-media thickness, and endothelial function. Results: There was no difference between biochemical values, systolic function, left ventricular dimensions, and carotid intima-media thicknesses in the three evaluation periods. There were significant increases in the body mass index, body weight, and systolic/diastolic blood pressure measurements at 1 week and 3 months after treatment (p<0.001). There was a significant decrease in brachial artery flow-mediated relaxation at 1 week and 3 months (1 versus 2, p=0.042; 1 versus 3, p=0.003). In Doppler measurements at 1 week and 3 months, there was an increase in mitral A velocity, IVRT, and EDT values and a decrease in the E/A ratio in line with diastolic dysfunction. Conclusion: Pulse steroid therapy used for demyelinating diseases deteriorated endothelial and left ventricular diastolic functions in the early and late periods. Future studies are needed to evaluate the development of cardiovascular mortality and morbidity in patients receiving this type of treatment.en_US
dc.language.isoengen_US
dc.relation.isversionof10.14744/AnatolJCardiol.2016.7425en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDemyelinating diseasesen_US
dc.subjectDiastolic functionen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectPulse steroiden_US
dc.titleThe effect of high-dose steroid treatment used for the treatment of acute demyelinating diseases on endothelial and cardiac functionsen_US
dc.typearticleen_US
dc.relation.journalANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.identifier.volume17en_US
dc.identifier.issue5en_US
dc.identifier.startpage392en_US
dc.identifier.endpage397en_US
dc.identifier.wos000403533300010en_US
dc.identifier.scopus2-s2.0-85018893159en_US
dc.contributor.pubmedID27965510en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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